GRAVIOLA
Peruvian Herbal remedies with reported anti-tumoral/anti-cancer effects
Contains over 14 different acetogenins

| Home | Anti-Anging | Arthritis | Anti-Cancer | Detoxifier | Diabetes | Kidney Stones | Fatigue Lack of Energy High Cholesterol | Hypertension |
| Libido problems | Menopause | Hepatitis | BPH Prostate | Libido Erectyle | Immune Problems | Overweight | Inca Peanut | Longevity |
|
Virus Shield - Flu- Influenza | Rain Forests | Cool info | About Us | Andes | links | the Incas | PERU TOP Superfoods |

Buy the Best Maca
                  extract available in the Market the Organic
                  gelatinized Maca each tab contains the higher
                  concentration of maca root 800mg per tab.
Buy Maca easy We
                accept major credit cards as well as PayPal - Shipping
                worldwide since 1996 BUY MACA
Home
Herbals
Order your Herbals
PERU Rain Forest
PERU the land of the Incas
Herbs Research
Write to sales@peruherbals.com
Camu Camu - Zamu The most powerful anti-oxidant, that boost the inmune system there are hundred of reports about cancer and the camu camu fruit
Learn why many people experience digestive disorders such as diarrhea while traveling. (Click Here)
We also suggest for the Cancer diet, to include the Camu Camu, because its high content of Vitamin C and and Cats Claw two powerful natural herbs that boost the inmune system and it is not acid so digestive system will be not affected with side effects,certainly will help with your disease and are 100% Natural We recently include in to your weapons as anti cancer herbs the Graviola Tea. ( this is the most natural and powerful way to fight against tumors and cancer cells.( Read a recent report of Purdue University about their findings in the Graviola leaves
 
Scientics and researchers knows that cancer requires an acidic and low oxygen environment to survive and flourish. research on cancer has proven that terminal cancer patients have an acidity level of 1,000 times more than normal healthy people. The reason is simple. Without oxygen, glucose undergoing fermentation becomes lactic acid. This causes the pH of the cell to drop. Sometimes, the level can even fall to 6.0 and 5.7 or lower. The truth behind this fact is that our human nature cannot fight diseases if our pH is not properly balanced. The Camu Camu a Peruvian amazon berry can help you to balance the ph levels in your body two tabs in the morning will be basic suggestion.

Dr. Johanna Budwig who support their theory with over 50 years in cancer research:
Graviola extract Annona muricata
 
The graviola it is a Peruvian fruit that its roots are so powerful to attack the maling cancer cells only without any damage of other good cells. Buy the best organic Graviola at Peruherbals.com
The Unique Peruvian herb so powerful that attack directly the malign cells as a missile each tab contains 100mg of full TNT. Pack 200 tabs. Enough for over three months supply . Plus S&H
 
  • Anti Cancer
  • Anti Tumoral
  • Anti Aging
  • Cancer multi drug resistant
  • Celular protector
 
 
 
 
Certify-Organic-Product
 

We strongly sugest to order the Peruvian Camu Camu. That is required to boost the inmune system in any cancer and tumoral problem. the camu camu it is a native amazonian fruit that it is ten times more powerful than an other regular vitamin "C"with the additional advantage that is is none acid and for that doesn´t have side effects. the camu camu it is a superb anti-aging and anti-oxidant. A well known world celebrity from Australia just get the full breast cancer taking high doses of camu camu

.
What is Graviola Extract...! Other name "masassamba"

what is.

The Graviola it is and Anti cancerous, anti tumoral, cellular protector,hypotensive a powerful herbal remedy (used actually as fruit) a recent research indicates that the antitumorous acetogenins are selectively toxic to just cancer cells.The annonacin is main natural active substance. Graviola may be used as a complementary therapy to cancer protocols

Graviola contains Annonaceous Acetogenins which have remarkable cytotoxic, anti-tumor activities. Their research identified more than 40 compounds with anti-cancer properties capable of killing cancer cells. One of the compounds ‘bullatacin’ was reported to kill multi-resistant cells on human mammary cancer cells by inhibiting the production of an ATP (adenosine triphosphate) which is energy-carrying molecules found in the cells of all living things, that is essential to all cell processes.

In Peru there are several anti cancer herbs, medicinal herbs or as an alternative cancer treatments but the Guanaba or the Graviola
Annonaceous acetogenins are effective in killing tumors that have proven resistant to anti-cancer agents, but may also to destroy it.

Some of the most powerful herbs are very useful for cancer alternative treatments:are Graviola (Guanabana) , Cats Claw, Achiote, Purple Corn, Camu Camu A Reserch study held in Japan on March 2002 who were studying various acetogenins found in several species of plants. They inoculated mice with lung cancer cells. One third received nothing (the control group), one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreated control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6% reduction of tumor mass over the control group—but 50% of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibited by 57.9%—slightly better than adriamycin—and without toxicity. This led the researchers to summarize;

“This suggested that "annonacin" was less toxic in mice. On considering the anti tumoral activity and toxicity, annonacin might be used as a lead to develop a potential anticancer agent.


Graviola Phytochemicals.

Acetaldehyde, Amyl-caproate, Amyloid, Annonain,
Anomuricine, Anomuricinine, Anomurine, Anonol,
Atherosperminine, Beta-sitosterol, Campesterol,
Cellobiose, Citric-acid, Citrulline, Coclaurine,
Coreximine, Dextrose, Ethanol, Folacin, Fructose,
Gaba, Galactomannan, Geranyl-caproate Glucose,
HCN, Isocitric-acid, Lignoceric-acid, Malic-acid,
Manganese, Mericyl-alcohol, Methanol, Methyl-hex-2-
enoate, Methyl-hexanoate, Muricine, Muricinine,
Muricapentocin, Muricoreacin,
Myristic-acid, Pcoumaric-acid,
Paraffin, Potassium-chloride,
Procyanidin, Reticuline, Scyllitol, Stearic-acid,
Stepharine, Stigmasterol, Sucrose, Tannin, Xylosylcellulos

Graviola Benefits
Many active compounds and chemicals have been found in graviola, as scientists have been studying its properties since the 1940s. Most of the research on graviola focuses on a novel set of chemicals called Annonaceous acetogenins. Graviola produces these natural compounds in its leaf and stem, bark, and fruit seeds. Three separate research groups have confirmed that these chemicals have significant antitumorous properties and selective toxicity against various types of cancer cells (without harming healthy cells) publishing eight clinical studies on their findings. Many of the acetogenins have demonstrated selective toxicity to tumor cells at very low dosages—as little as 1 part per million. Four studies were published in 1998 which further specify the chemicals and acetogenins in graviola which are demonstrating the strongest anticancerous, antitumorous, and antiviral properties. In a 1997 clinical study, novel alkaloids found in graviola fruit exhibited antidepressive effects in animals.

Graviola Research
Annonaceous acetogenins are only found in the Annonaceae family (to which graviola belongs). These chemicals in general have been documented with antitumorous, antiparasitic, insecticidal, and antimicrobial activities. Mode of action studies in three separate laboratories have recently determined that these acetogenins are superb inhibitors of enzyme processes that are only found in the membranes of cancerous tumor cells. This is why they are toxic to cancer cells but have no toxicity to healthy cells. Purdue University, in West Lafayette, Indiana, has conducted a great deal of the research on the acetogenins, much of which, has been funded by The National Cancer Institute and/or the National Institute of Health (NIH). Thus far, Purdue University and/or its staff have filed at least nine U.S. and/or international patents on their work around the antitumorous and

A research from Purdue University was reported that 14 different acetogenins tested thus far demonstrate potent ATP-blocking properties (including several found only in graviola). They also reported that 13 of these 14 acetogenins tested were more potent against MDR breast cancer cells than all three of the standard drugs (adriamycin, vincristine, and vinblastine) they used as controls. Plant Chemicals

Properties and uses of these acetogenins.
In 1997, Purdue University published information with promising news that several of the Annonaceous acetogenins were " . . . not only are effective in killing tumors that have proven resistant to anti-cancer agents, but also seem to have a special affinity for such resistant cells." In several interviews after this information was publicized, the head pharmacologist in Purdue's research explained how this worked. As he explains it, cancer cells that survive chemotherapy can develop resistance to the agent originally used as well as to other, even unrelated, drugs. This phenomenon is called multi-drug resistance (MDR). One of the main ways that cancer cells develop resistance to
chemotherapy drugs is by creating an intercellular pump which is capable of pushing anticancer agents out of the cell before they can kill it. On average, only about two percent of the cancer cells in any given person might develop this pump—but they are the two percent that can eventually grow and expand to create multi-drug-resistant tumors. Some of the latest research on acetogenins reported that they were capable of shutting down these intercellular pumps, thereby killing multi-drug-resistant tumors. Purdue researchers reported that the acetogenins preferentially killed multi-drug-resistant cancer cells by blocking the transfer of ATP—the chief source of cellular energy—into them. A tumor cell needs energy to grow and reproduce, and a great deal more to run its pump and expel attacking agents. By inhibiting energy to the cell , it can no longer run its pump. When acetogenins block ATP to the tumor cell over time, the cell no longer has enough energy to operate sustaining processes—and it dies. Normal cells seldom develop such a pump; therefore, they don't require large amounts of energy to run a pump and, generally, are not adversely affected by ATP inhibitors. Purdue researchers reported that 14 different acetogenins tested thus far demonstrate potent ATP-blocking properties (including several found only in graviola). They also reported that 13 of these 14 acetogenins tested were more potent against MDR breast cancer cells than all three of the standard drugs (adriamycin, vincristine, and vinblastine) they used as controls.

The Annonaceous acetogenins discovered in graviola thus far include: annocatalin, annohexocin, annomonicin, annomontacin, annomuricatin A & B, annomuricin A thru E, annomutacin, annonacin, annonacinone, annopentocin A thru C, cis-annonacin, cis-corossolone, cohibin A thru D, corepoxylone, coronin, corossolin, corossolone, donhexocin, epomuricenin A & B, gigantetrocin, gigantetrocin A & B, gigantetrocinone, gigantetronenin, goniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muricatetrocin A & B muricatin D, muricatocin A thru C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin, solamin, uvariamicin I & IV, xylomaticin

Biological Activites and Clinical Research
In an 1976 plant screening program by the National Cancer Institute, graviola leaves and stem showed active toxicity against cancer cells and researchers have been following up on these findings since. Thus far, specific acetogenins in graviola and/or extracts of graviola have been reported to be selectively toxic in vitro to these types of tumor cells: lung carcinoma cell lines; human breast solid tumor lines; prostate adenocarcinoma; pancreatic carcinoma cell lines; colon adenocarcinoma cell lines; liver cancer cell lines; human lymphoma cell lines; and multi-drug resistant human breast adenocarcinoma. Researchers in Taiwan reported in 2003 that the main graviola acetogenin, annonacin, was highly toxic to ovarian, cervical, breast, bladder and skin cancer cell lines at very low dosages saying; ". . . annonacin is a promising anti-cancer agent and worthy of further animal studies and, we would hope, clinical trials."

An interesting in vivo study was published in March of 2002 by researchers in Japan, who were studying various acetogenins found in several species of plants. They inoculated mice with lung cancer cells. One third received nothing (the control group), one third received the chemotherapy drug adriamycin, and one third received the main graviola acetogenin, annonacin (at a dosage of 10 mg/kg). At the end of two weeks, five of the six in the untreated control group were still alive and lung tumor sizes were then measured. The adriamycin group showed a 54.6% reduction of tumor mass over the control group—but 50% of the animals had died from toxicity (three of six). The mice receiving annonacin were all still alive, and the tumors were inhibited by 57.9%—slightly better than adriamycin—and without toxicity. This led the researchers to summarize; "This suggested that annonacin was less toxic in mice. On considering the antitumor activity and toxicity, annonacin might be used as a lead to develop a potential anticancer agent."

Uses
Cancer research is ongoing on these important Annona plants and plant chemicals, as several pharmaceutical companies and universities continue to research, test, patent, and attempt to synthesize these chemicals into new chemotherapeutic drugs. In fact, graviola seems to be following the same path as another well known cancer drug - Taxol. From the time researchers first discovered an antitumorous effect in the bark of the pacific yew tree and a novel chemical called taxol was discovered in its bark - it took thirty years of research by numerous pharmaceutical companies, universities, and government agencies before the first FDA-approved Taxol drug was sold to a cancer patient (which was based on the natural taxol chemical they found in the tree bark). With graviola, it has taken researchers almost 10 years to successfully synthesize (chemically reproduce) the main antitumorous chemical, annonacin. These acetogenin chemicals have a unique waxy center and other unique molecular energy properties which thwarted earlier attempts, and at least one major pharmaceutical company gave up in the process (despite knowing how active the natural chemical was against tumors). Now that scientists have the ability to recreate this chemical and several other active acetogenins in the laboratory, the next step is to change the chemical just enough (without losing any of the antitumorous actions in the process) to become a novel chemical which can be patented and turned into a new patented cancer drug. (Naturally-occurring plant chemicals cannot be patented.) Thus far, scientists seem to be thwarted again—every time they change the chemical enough to be patentable, they lose much of the antitumorous actions. Like the development of taxol, it may well take government agenies like the National Cancer Institute and the National Institute of Health to step forward and launch full-scale human cancer research on the synthesized unpatentable natural plant chemical (which will allow any pharmaceutical company to develop a cancer drug utilizing the research as happened with taxol) to be able to make this promising therapy available to cancer patients in a timely fashion.

In the meantime, many cancer patients and health practitioners are not waiting… they are adding the natural leaf and stem of graviola (with over 40 documented naturally-occurring acetogenins including annonacin) as a complementary therapy to their cancer protocols. After all, graviola has a long history of safe use as a herbal remedy for other conditions for many years, and research indicates that the antitumorous acetogenins are selectively toxic to just cancer cells and not healthy cells—and in miniscule amounts. While research confirms that these antitumorous acetogenins also occur in high amounts in the fruit seeds and roots of graviola, different alkaloid chemicals in the seeds and roots have shown some preliminary in vitro neurotoxic effects. Researchers have suggested that these alkaloids might be linked to atypical Parkinson's disease in countries where the seeds are employed as a common herbal parasite remedy. Therefore, using the seeds and root of graviola is not recommended at this time.

The therapuetic dosage of graviola leaf, (which offers just as high of an amount of acetogenins as the root and almost as much as the seed) is reported to be 2-3 grams taken 3 or 4 times daily. Graviola products (capsules and tinctures) are becoming more widely available in the U.S. market, and now offered under several different manufacturer's labels in health food stores. As one of graviola's mechanisms of action is to deplete ATP energy to cancer cells, combining it with other supplements and natural products which increase or enhance cellular ATP may reduce the effect of graviola. The main supplement which increases ATP is a common antioxidant called Coenzyme Q10 and for this reason, it should be avoided when taking graviola.

Graviola is certainly a promising natural remedy and one that again emphasizes the importance of preserving our remaining rainforest ecosystems. Perhaps—if enough people believe that the possible cure for cancer truly is locked away in a rainforest plant—we will take the steps needed to protect our remaining rainforests from destruction. One researcher studying graviola summarized this idea eloquently: "At the time of preparation of this current review, over 350 Annonaceous acetogenins have been isolated from 37 species. Our preliminary efforts show that about 50%, of over 80 Annonaceous species screened, are significantly bioactive and are worthy of fractionation; thus, this class of compounds can be expected to continue to grow at an exponential rate in the future, provided that financial support for such research efforts can be found. With the demise of the world's tropical rain forests, such work is compelling before the great chemical diversity, contained within these endangered species, is lost."
The Annonaceous acetogenins discovered in graviola thus far include:

annocatalin,
annohexocin
annomonicin,
annomuricatin A & B
annomuricin A thru E,
annomutacin,
annonacin,
annonacinone
,annopentocin A thru C,
cis-annonacin,
cis-corossolone
cohibin A thru D
corepoxylone
coronin, corossolin corossolone
donhexocin
epomuricenin A & B
gigantetrocin
gigantetrocin A & B
gigantetrocinone
gigantetronenin, g
oniothalamicin, iso-annonacin, javoricin, montanacin, montecristin, muracin A thru G, muricapentocin, muricatalicin, muricatalin, muri-catenol, muricatetrocin A & B muricatin D, muricatocin A thru C muricin H, muricin I, muricoreacin, murihexocin 3, murihexocin A thru C, murihexol, murisolin, robustocin, rolliniastatin 1 & 2, saba-delin,solamin, uvariamicin I & IV, xylomaticin
Herbal remedies medicines with reported anti-tumor/anti-cancer effects

Cat´s Claw, Camu Camu, Achiote, Purple Corn, Curcuma, Maca, Kiwicha, Quinua

Calories

61.3-53.1

Humidity

82.8g

Protein

1.00g

Fat

0.97g

Carbohydrates

14.63g

Fiber

0.79g

Ash

60g

Calcium

10.3 mg

Phosphorus

27.7 mg

Iron

0.64 mg

Vitamin A (B-carotene)

0

Thiamin

0.11 mg

Riboflavin

0.05 mg

Niacin

1.28mg

Ascorbic Acid

29.6 mg

Amino acids:

 

tryptophan

11 mg

methionine

7 mg

lysine

60 mg

Graviola side effects: No side effects have been reported until this time

Studies, published in two separate journal articles, show that the Graviola, also known as Paw paw, compounds not only are effective in killing tumors that have resistance to anti-cancer agents, but also seem to have a special affinity for such resistant cells. The findings were detailed in the l Cancer Letters and the Journal of Medicinal Chemistry. We also suggest to read more about Camu Camu, Purple Corn and Cat´s Claw

References:


Kim, G. S., et al. “Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of Annona muricata.” J. Nat. Prod. 1998; 61(4): 432-36.
Nicolas, H., et al. “Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997; 40(13): 2102-6.
Zeng, L., et al. “Five new monotetrahydrofuran ring acetogenins from the leaves of Annona muricata.” J. Nat. Prod. 1996; 59(11): 1035-42.
Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran Annonaceous acetogenins, annomuricins A and B, from the leaves of Annona muricata.Chang, F. R., et al. “Novel cytotoxic Annonaceous acetogenins from Annona muricata.” J. Nat. Prod. 2001; 64(7): 925-31.
Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.” Fitoterapia. 2000; 71 (2): 183-6.
Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.” Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-35.
Kim, G. S., et al. “Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata.” Phytochemistry. 1998; 49(2): 565-71.” J. Nat. Prod. 1995; 58(6): 830-36.
Oberlies, N. H., et al. “Tumor cell growth inhibition by several Annonaceous acetogenins in an in vitro disk diffusion assay.” Cancer Lett. 1995; 96(1): 55-62.
Wu, F. E., et al. “Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(9): 1430-37.
Wu, F. E., et al. “New bioactive monotetrahydrofuran Annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 909-5.


suggested dose : 2 tabs three times a day after two weeks discontinue the treatment for (2) days then re-start again

 




Order Here Graviola Extract



The Super Maca it is a mix of native peruvian super foods to boost the energy.
Maca root
The Cats Claw it is suggested for arthritis and joint problems
Cat´s Claw Anti Cancer Properties
Yacon it is suggested for liver problems
Yacon Tabs
BE FREE !!
Click here to ORDER
 
If you are a serious cancer fighter then it is suggested that you include six grams of broccoli daily it is a powerful anti-cancer vegetable. Also you must include a high concentrate dossis of vitamin "C" as Camu Camu. Mother nature provide all the tools to be healthy but none helathjy formula it is complete if you do not include a Pray to God. ask that you want to to do his will..
Other Anti Cancer and Anti Tumoral herbs
That include graviola, Camu Camu, Graviola, Purple Corn, Cats Claw

 



V

 
Copyright © 2002 Peruherbals Inc

Disclaimer: The information presented is for information purposes only. It is based on scientific studies or traditional usage. Consult a health care professional before using supplements or making any changes in prescribed medications. Information and statements regarding dietary supplements have not been evaluated by the Food and Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease.